Advanced glycation end products in diabetic cardiomyopathy: An alternative hypothesis
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products in diabetic corneas.
PURPOSE Corneal complications are often associated with diabetes mellitus and can be vision threatening. Corneas in diabetic patients are exposed to increased glucose concentration despite cornea's avascular property, and this condition may contribute to the accumulation of advanced glycation end products (AGEs). The focus of this study was to examine the role of AGEs in the pathogenesis of dia...
متن کاملAdvanced glycation end-products in diabetic nephropathy
Throughout the industrialized (well-fed) Adverse effects of hyperglycaemia, once thought an epiphenomenon in the pathogenesis of diabetic microworld, diabetes mellitus is the most prevalent cause of end-stage renal disease (ESRD). Diabetic nephropathy and macrovascular complications, presently are a central focus of active clinical and basic investigation is as likely to develop in long-duratio...
متن کاملAdvanced glycation end products and diabetic nephropathy.
Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy. Their importance as downstream mediators of tissue in...
متن کاملAdvanced Glycation End Products and Diabetic Complications
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other di...
متن کاملAdvanced glycation end products
Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particula...
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ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2011
ISSN: 1053-2498
DOI: 10.1016/j.healun.2011.06.004